林伯樵實驗室 (the research group of Dr. Po-Chiao Lin)

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恭喜老闆Po-Chiao Lin(LPC)榮獲102學年度年輕學者獎暨103學年度特聘年輕學者

遲來的生日禮物&教師節禮物~~老師生日快樂&教師節快樂!!!

LPC said:

Thanks all you guys in LPC group! Let's dream all incredibly crazy but amizing chemistry all the time. Probably someday we can guide cell tells us what happens inside it!
呼，我們實驗室總算有受到一點小小的肯定!不過離目標還早呢，繼續加油吧!LPCs, go go go!

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本實驗室於2014年最新研究成果發表於美國化學會有機化學期刊  Organic Letters

利用銅(Cu)金屬催化形成triazole之產物,再進一步一鍋化利用銠(Rh)金屬催化合環形成吲哚(Indole)之衍生物 

後續之合成應用亦正在積極開發中!

ABSTRACT: An efficient Cu/Rh-catalyzed method is proposed for the synthesis of 3-indolylimines from N-propargylanilines through Rh(II)-catalyzed denitrogenative annulation of N-sulfonyl-1,2,3-triazoles. Further combined with hydrolysis or reduction, a one-pot method is developed to enable the direct incorporation of an imine, aldehyde, or amine group into an indole system from an alkyne. A variety of substituted 3-indolylimines, indole-3-carboxaldehydes, and 3-Indolylmethanamines are synthesized in good yields.

本研究發表於

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本實驗室成功開發極具重要性之無殘留式醣蛋白專一性化學探針。並成功應用於醣蛋白晶片之研究。

此研究成果發表於聲譽卓著之美國化學會化學生物學期刊 (ACS Chem. Biol. 2014, 9, 390.)

http://pubs.acs.org/doi/abs/10.1021/cb400631w

ABSTRACT: A new chemical method for the traceless labeling of glycoproteins with synthetic boronic acid (BA)-tosyl probes was successfully developed. The BA moiety acts as an affinity head to direct the formation of a cyclic boronate diester with the diol groups of glycans. Following this step, the electrophilic tosyl group is displaced by an S_N2 reaction with a nucleophilic residue of the boronated glycoprotein, and finally, a reporter group is tagged onto the glycoprotein via an ether linkage. In the presence of polyols, a competition reaction recovers the native glycan of the tagged glycoprotein, conserving its biological significance. The BA-tosyl probes were used successfully for the specific labeling of glycosylated fetuins in a mixed protein pool and from crude Escherichia coli (E. coli) lysate. Further, a BA-tosyl–functionalized glass slide was used to fabricate glycoprotein microarrays with highly conserved glycans. By interacting with various lectins (carbohydrate-binding proteins), such as Concanavalin A (Con A) and wheat germ agglutinin (WGA), the types of carbohydrates and specific linkages of glycoproteins (α or β) could be systematically monitored. It is believed that the newly developed method will greatly accelerate the understanding of glycoproteins.

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本實驗室於2014年之研究成果:A mild removal of Fmoc group using sodium azide

利用中性之溫和條件有效率進行Fmoc保護基團之移除。並成功應用於小分子及胜肽之合成

發表於:Amino Acids 2014, 46, 367.

Abstract : A mild method for effectively removing the
fluorenylmethoxycarbonyl (Fmoc) group using sodium

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本實驗室於2014年最新研究成果發表於美國化學會有機化學期刊 The Journal of Organic Chemistry

利用一價銅催化之Dihydropyrimidinone之合成及其在beta-amino acid衍申物之合成

後續之合成應用亦正在積極開發中!

A copper(I)-catalyzed synthesis of substituted dihydropyrimidin-4-ones from propargyl amides via the formation
of ketenimine intermediate has been successfully developed; the synthesis afforded good isolated yields (80−95%). The mild

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駿其&淨成 生日快樂 

烤肉之前先 乾杯!!

下雨也要烤!!!

呼呼 燒起來啦!

 地瓜哥哥秀肌肉

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 為了慰勞大家2013年一年的辛勞,歲末來一次墾丁行!!!

check in 中

 Sexy~

 LPCgroup 卡丁車賽

 LPC特戰隊!!

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恭喜本實驗室 陳駿其同學榮獲「長興化工獎學金」三萬元整!

                   周志鴻同學榮獲「102學年度研究生獎學金」二十四萬元整

                   !  

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LPC's Lab 研究生 & 專題生

 ~近期活動照片~ 

博士生 (Ph. D students)

陳駿其 (Chun-Chi Chen)  貝司克(Basker Rajagopal)   周志鴻(Chih-Hung Chou)

碩士生 (Master students)

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