林伯樵實驗室 (the research group of Dr. Po-Chiao Lin)

本實驗室於2014年最新研究成果發表於美國化學會有機化學期刊 The Journal of Organic Chemistry

利用一價銅催化之Dihydropyrimidinone之合成及其在beta-amino acid衍申物之合成

後續之合成應用亦正在積極開發中!

A copper(I)-catalyzed synthesis of substituted dihydropyrimidin-4-ones from propargyl amides via the formation
of ketenimine intermediate has been successfully developed; the synthesis afforded good isolated yields (80−95%). The mild
reaction conditions at room temperature allow the reaction to proceed to completion in a few hours without altering the
stereochemistry. Further, by involving a variety of reactive nucleophiles, the obtained substituted dihydropyrimidin-4-ones were
elegantly transformed into the corresponding β- and β3-amino acid analogues.

本研究工作發表於下列期刊:

J. Org. Chem. 2014, 79, 1254.

http://pubs.acs.org/doi/abs/10.1021/jo402670d