林伯樵實驗室 (the research group of Dr. Po-Chiao Lin)

本實驗室於2014年最新研究成果發表於美國化學會有機化學期刊  Organic Letters

利用銅(Cu)金屬催化形成triazole之產物,再進一步一鍋化利用銠(Rh)金屬催化合環形成吲哚(Indole)之衍生物 

後續之合成應用亦正在積極開發中!

ABSTRACT: An efficient Cu/Rh-catalyzed method is proposed for the synthesis of 3-indolylimines from N-propargylanilines through Rh(II)-catalyzed denitrogenative annulation of N-sulfonyl-1,2,3-triazoles. Further combined with hydrolysis or reduction, a one-pot method is developed to enable the direct incorporation of an imine, aldehyde, or amine group into an indole system from an alkyne. A variety of substituted 3-indolylimines, indole-3-carboxaldehydes, and 3-Indolylmethanamines are synthesized in good yields.

本研究發表於